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Facility Overview

The Athymic Animal & Preclinical Therapeutics Shared Resource consists of two physical sites, one at ÐÇ¿Õ´«Ã½ and one at Cleveland Clinic at the Taussig Cancer Institute. The purpose of the facility is to help principal investigators of ÐÇ¿Õ´«Ã½ and Cleveland Clinic perform tumor experiments, angiogenesis studies, and pharmacokinetic studies in mice. The facility routinely conducts animal experiments involving several syngeneic murine tumor models, and several human xenograft (athymic nude mouse, and NSG – NOD scid IL2Rg mouse) tumor models. In addition, the facility has developed several orthotopic tumor models: brain, lung, breast, renal, spleen, skin, ovarian, prostate, bladder, and pancreas. The facility is always willing to develop additional new models.

Resources

• Laminar flow work station
• Laboratory work room containing two laminar flow hoods and a type B, 100% exhaust biohazard hood to accommodate preparation of cancer cells, anticancer agents, and other pharmaceutical agents
• Full complement of stainless steel surgical instruments
• Pass-through autoclave connecting the three animal rooms
• Steris "super-autoclave" installed adjacent to the facility as a backup

Services

The Athymic Animal & Preclinical Therapeutics Shared Resource utilizes murine models to facilitate in vivo cancer drug screening, drug evaluation and drug development. Services include drug administration (sub-cutaneous, intravenous, intraperitoneal, prolonged slow-release silastic capsule), blood drawing (repetitive - saphenous vein, or terminal – cardiac puncture) for pharmacokinetic pharmacodynamic (PK/PD) studies, absorption distribution metabolism excretion (ADME) studies, syngeneic and xenograft tumor models, orthotopic tumor models. Services provided help in evaluation of new pharmacologic agents by providing data on tumor growth, metastasis, angiogenesis and gene expression. The facility also provides consultation services to assist the investigator in all aspects of animal tumor model development.

Fees

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